Data Interpretation:
Platelet Function Testing

Question 1

Study the following aggregation traces and establish the diagnosis.
Remember there may be more than one possible answer for each set of aggregation traces.

 

Question 2

Study the following aggregation traces and establish the diagnosis.
Remember there may be more than one possible answer for each set of aggregation traces.

Question 3

Study the following aggregation traces and establish the diagnosis.
Remember there may be more than one possible answer for each set of aggregation traces.

 

Question 4

Using the data shown below for a VWF:RCo assay using platelets - calculate the VWF:RCO in Plasma Sample 1 and 2 [the two samples are shown at the bottom].

1. Assume the reference plasma has a VWF:RCo of 100%.
2. Remember to plot your slopes on double log paper with the dilutions on the X-axis and the slopes on the Y axis.

If you need a larger version of these traces to print out - click HERE.

Question 5

These traces are from a patient with suspected Von Willebrands Disease. What do they show and what is the diagnosis?

Figure 1: Patient Plasma + Control Platelets

Figure 2: Patient Platelets + Control Plasma

 

Question 6

Study the following aggregationtraces. What is the diagnosis?

 

Question 7

Study the following aggregationtraces. What is the diagnosis?

 

Question 8

Study the following aggregationtraces. What is the diagnosis?

 

Question 9

Study the following aggregationtraces. What is the diagnosis?

 

 

Question 10

Study the following aggregationtraces. What is the diagnosis?

Question 10

In patients with Glanzmann’s thrombasthenia:

a. Why is there relatively normal 'aggregation' to ristocetin?

b. Why do some patients with Glanzmann’s thrombasthenia become refractory to platelets?

 

 

 

 

 

Click HERE for the Answers!

Try to resist the temptation to look at the answers before you work through all the questions!